Expert Manually Curated
Precision medicine Knowladgebase


iCMDB Knowledge Base for Precision Medicine

Expert Manually Curated Precision Medicine Knowledgebase



Infectious Diseases

Diseases Risk

What is iCMDB™

iCMDB™ (Individual Customized Medicine Database) is an integrated sequence analysis platform. It is tailored to clinicians in conducting personalized treatments based on patients’ genetic profiles.

  • Analyse Consolidated Data from Sanger and Next-Gen Sequencing, qPCR, FISH
  • Compatible with All Sequencers on Market
  • Fully Automated Analysis Pipeline
  • Comprehensive and Manually Curated Annotation Database
  • Highly-Customizable Clinical Report with Treatment Plan Suggestions
  • ISO13485 Certified
  • Registered as HSA Class A Medical Device
Knowladgebase Gene / Genotype Variants Annotations Drugs
Solid Tumour 813 1691 4615 389
Liquid Cancer 171 378 724 133
PGx 1709 - 3684 542
Diseases Risk 809 4640 6130

Knowledgebase Curation

  • Comprehensive coverage of genomic variants as well as gene and protein expression alterations.
  • Scientific mechanism and clinical interpretation of association with disease diagnosis, prognosis, and treatment.
  • Integration with public database to allow user-led investigation of variants.
  • Prevalence of genomic variants in various cancer types and MAFs in different populations.
  • EBM evidence classification to support confident decision making.
  • Full collection of FDA approved and investigational treatment.
  • Concordance with HGVS nomenclature and clinical guidelines.

iCMDB® Knowledgebase Curation Steps

Identify Biomarkers
  • Solid Tumors (CRC, NSCLC, Gastric, etc.)
  • Hematological Malignancies (AML, CLL, NHL, etc.)
Collecting Variants
  • Point Mutation
  • Deletion
  • Insertion
  • Fusion
  • Complex Region-based Variation
  • CNV
  • SNP
  • Overexpression
Curating Annotations
  • Diagnosis
  • Prognosis
  • Chemotherapy
  • Targeted Therapy
Adding Treatment Plans
  • FDA Approved
  • 1st/2nd Line
  • Under Clinical Investigation

iCMDB® Knowledgebase Curation

  • Manually curated by scientists (PhDs, MScs)
  • SOPs (Standard Operation Protocols) to standardize format
  • Multiple levels of review
  • Reputable and original resources
  • Curated follow Evidence-Based Medicine (EBM) principles
  • Continuous update
  • Integration of population-unique genetic background information

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